Rabbit Antibodies - A New Source of Therapeutics, A New Standard of Care:
Apexigen's rabbit antibody technology may hold the key to overcoming the limitations of other antibody technologies. For decades, scientists have made ground-breaking discoveries with rabbit antibodies in research settings, being drawn to them by their unmatched diversity of unique high quality antibodies – with high affinity, high specificity and the ability to recognize unique epitopes. Importantly, this diversity provides critical advantages for the discovery of therapeutic antibodies:
The rabbit immune system is able to create a greater diversity (than either the mouse or man) of unique antibodies to a target because it primarily uses a mechanism called gene conversion, which is not used by man or rodent species, to create antibody diversity. Gene conversion allows the rabbit immune system to create “unlimited” diversity of its antibody repertoire.
Novel Humanization Technology: the MLG Technology
The company’s proprietary Mutation Lineage Guided (MLG) humanization technology is a novel approach that represents a significant departure from standard mouse antibody humanization processes. MLG utilizes the large amount of information derived from the diversity of antibody sequences generated by the rabbit, to humanize the entire antibody and achieve a very high degree of humanization. Residues in both the framework and the CDRs (Complementarity Determining Regions) can be humanized through this method. The results are antibodies that retain full activity, offering key benefits compared to other humanization technologies that tend to produce antibodies with reduced affinity and potency.